Triprolidine (HCI) is antihistamine. Triprolidine (HCI) is effective in the symptomatic treatment of seasonal and perennial allergic rhinitis, allergic conjunctivitis and uncomplicated skin manifestation of urticaria etc.
Mechanism Of Action
Triprolidine primarily works by blocking the H1 histamine receptors, thereby preventing histamine from causing allergy symptoms. Its anticholinergic properties also contribute to its effectiveness by providing mild sedation and drying up secretions. This makes triprolidine effective in treating various allergic conditions and symptoms.
Chemically Identification
Triprolidine is chemically identified as (E)-2-3-(1-Pyrrolidinyl)-1-p-tolylprop-1-enyl]pyridine. It consists of a pyridine ring, a tolyl group, and a pyrrolidine ring.
Uses
Triprolidine (HCI) is primarily indicated in conditions like:
- Allergic conjunctivitis
- Allergic rhinitis Angioedema
- Angioedema
- Common cold
- Fever
- Urticaria
Side Effects
The signs and symptoms that are produced after the acute overdosage of Triprolidine (HCI) include:
- Convulsions
- Respiratory depression
- Dizziness
- Incoordination
- Weakness
The symptomatic adverse reactions produced by Triprolidine (HCI) are more or less tolerable and if they become severe, they can be treated symptomatically, these include:
- Headache
- Drowsiness
- Anorexia
- Palpitation
- Tinnitus
- Blurred vision
- Confusion
- Epigastric discomfort
- Dysuria
- Photosensitivity
- Postural hypotension
- Skin eruptions
- Somnolence
- Urinary frequency
- GI disturbance
- Lassitude
Brand Names
- Actidil
- Myidil
- Tripon
- Histafed
- Tripohist
- Mydrilate
- Allermax
- Allerphed
Administration
- Take with or without food.
- Do not exceed recommended dose.
- Use measuring device (e.g., spoon or syringe) for accurate dosage
- Do not give to children under 6 years without consulting a pediatrician.
Dosage
Adults and Children over 12 years:
- Tablets or Capsules: 2.5-5 mg every 4-6 hours, not to exceed 20 mg in 24 hours
- Syrup or Liquid: 1.25-2.5 mg every 4-6 hours, not to exceed 10 mg in 24 hours
Children 6-12 years:
- Tablets or Capsules: 1.25-2.5 mg every 4-6 hours, not to exceed 10 mg in 24 hours
- Syrup or Liquid: 0.625-1.25 mg every 4-6 hours, not to exceed 5 mg in 24 hours
Children under 6 years:
- Consult a pediatrician for dosage instructions
Contraindication
Triprolidine (HCI) is contraindicated in conditions like Alcohol dependence, Prostatic hypertrophy, Narrow-angle glaucoma, Hypersensitivity.
Warnings
Triprolidine should be used with caution in patients with asthma, glaucoma, ulcer, difficulty urinating due to an enlarged prostate gland, heart disease, high blood pressure, seizures or hyperthyroidism. Do not drink alcoholic beverages. This drug should be used only if clearly needed during pregnancy or lactation. Do not give this medication to a child younger than six years of age unless directed to do so by a doctor.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
FAQS
Can I overdose on Triprolidine?
If you suspect an overdose, seek medical attention immediately. Symptoms of overdose include excessive drowsiness, confusion, and seizures.
How long does Triprolidine take to work?
Triprolidine starts working within 30 minutes to 1 hour after taking it.
Can I take Triprolidine if I’m pregnant or breastfeeding?
Consult your doctor or pharmacist before taking Triprolidine if you’re pregnant or breastfeeding.
Can I drive or operate heavy machinery while taking Triprolidine?
Triprolidine may cause drowsiness, so use caution when driving or operating heavy machinery.
Disclaimer
The information provided on this platform is for general informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this platform.
